Biosyntrx strongly supports our friends at London-based US Ophthalmic Review,Touch Ophthalmology’s beautifully published, peer-reviewed biannual print and electronic journal.
Biosyntrx strongly supports our friends at London-based US Ophthalmic Review,Touch Ophthalmology’s beautifully published, peer-reviewed biannual print and electronic journal. It includes articles, case reports, practice guides, theoretical discussions, and original research. Three members of the Biosyntrx scientific advisory board are on their editorial board: Richard Lindstrom, MD, Roger Steinert, MD, and Biosyntrx president, Spencer Thornton, MD.
With Touch Ophthalmology’s permission, today’s Friday Pearl presents part one of an exceptionally well-produced, patient-focused dry eye treatment video from their e-journal by John Hovanesian, MD, as well as a brilliant “Disease Update on Human Tear Proteomes,” by Piera Versura and Emilio Campos.
Disease Update on Human Tear Proteome
“Tears are a critical body extracellular fluid coating surface epithelial cells of cornea and conjunctiva and providing the optically smooth surface necessary for refraction of light onto the retina.
“Production and quality of tears are controlled and coordinated by the lachrymal function unit (LFU), which consists of the main and accessory lachrymal glands, the ocular surface (including the cornea and conjunctiva), the meibomian glands and the interconnecting neural pathways. A great body of past literature established that the conditions of LFU are reflected in the composition of tears.
“Proteomics is the research area studying proteins expressed in a given biological compartment at a given time. The original definition of proteins as products of gene expression has lately included post-translational modifications of these gene products occurring in cell metabolism and turnover. These arguments and the concept of temporal dynamics are of specific relevance in a body fluid as tears, directly in tiny equilibrium with the external environment and continuously exposed to both internal and external noxious agents.
“Proteomic studies rely upon high-tech separation methods and equipment resolving the biological sample complexity, with the aid of procedures able to remove abundant proteins from samples (such as albumin and immunoglobulins in sera) and exhibit less abundant proteins.
“It is likely, however, that this pre-analytical step removes other possibly important protein biomarkers. An alternative option is to analyze body fluids closer to the site of interest: tears are a useful and accessible source for evaluating ocular surface tissue and lachrymal gland function in a number of disease conditions, such as dry eye, as well as treatment response.”
Tears contain proteins, peptides, lipids, small molecule metabolites and electrolytes. In recent years, increasing attention has been devoted to human tear proteon with the aim of developing disease biomarkers.
“In this article we summarize the most relevant literature in proteomic analysis of human tears and point out those proteins proposed as biomarkers in dry eye. Potential application of tear proteomics in the clinical setting and the related difficulties are also discussed.”
We highly recommend that our Friday Pearl readers interested in proteomic science and tear film proteins read the complete article, which can be accessed in the US Ophthalmic Review e-journal here.
Ellen Troyer, with Spencer Thornton, MD. and the Biosyntrx staff
PEARL: The Biosyntrx science team has always been interested in tear film proteins. Based on supporting science, lactoferrin, an iron-binding protein, is included in our oral dry eye formulation, BioTears. This is particularly important for the dry eye contact lens wearer to help prevent ocular surface viral or bacterial biofilm formation. The unique and patented combination of nutrients in BioTears helps restore biochemical balance of the three-layer tear film, thus improving dry eye symptoms and visual acuity.
References and a Crestpoint Management surgical instrument announcement can be found following today’s Pearl here.