In developing a second patented three layer tear-film-specific formula for oral administration, the Biosyntrx science team included the nutrient co-factors suggested necessary to address dry eye syndrome by physiologic rather than pharmacological means.
This is the same team team that opened the doors for the first nutrient-based oral dry eye therapy in 1998.
This current science-based combination of ingredients are designed to work synergistically rather than individually, and are suggested in published scientific literature to effectively address the inflammatory process responsible for most dry eye disease, as well as enhancing and restoring function to the glands involved in all three layers of the tear film.
As an example, BioTears now includes Green Tea catechins (EGCG), which are clinically suggested to help modulate tear film osmolarity, the current HOT topic in dry eye disease.
Optimal tear film structure and function are critical for excellent vision, particularly for multifocal intraocular lens recipients.
Clinical studies have suggested that efficacious amounts of the Omega-6 short chain fatty acid gamma-linolenic-acid (GLA) from Black Currant Seed Oil and the supporting nutrient co-factors included in BioTears, vitamins C, B6 and the mineral magnesium, may restore normal production of lubricants in the eyes via the delta-6 desaturase conversion to the mucosal tissue specific, anti-inflammatory, prostaglandin E1 (PGE-1).
Pharmaceutical grade cod liver oil, as a source of Omega 3 EPA/DHA, is germane to the BioTears formulation.
It serves as an excellent source of natural Vitamin A & D, which are both necessary for the base layer of the tear film. These nutrients are not provided by EE or TG fish oil.
Cod liver oil is also a metabolic gateway boost to the downstream conversion of Omega 3 fatty acids to the anti-inflammatory PGE3, while also preventing inappropriate Omega 6 arachidonic acid cleavage via the delta-5-destaurase enzyme (D5D).
Vitamin E, specifically gamma tocopherol, is suggested in peer-reviewed literature to stabilize and prevent fatty acid oxidation and inhibit COX2 enzyme activity that promotes an inflammatory response.
Curcumin is suggested in peer-reviewed literature to appropriately block Omega 6 fatty acids from metabolizing to the pro-inflammatory PGE2 and IL1.
Background: Curcumin is a natural COX2 inhibitor with similar chemical properties to ibuprofens Motrin and Advil (NSAIDS). The difference is Curcumin does not inhibit production of the COX1 enzyme that is necessary to protect the stomach lining.
Vitamin C, as ascorbic acid and fat-soluble ascorbyl palmitate, is suggested to best modulate prostaglandin (PGE1) synthesis due to the extended half-life of the fat-soluble vitamin C over water-soluble ascorbic acid. This Vitamin C, B6 and magnesium combination is also suggested in peer-reviewed literature to enhance the production of IgE concentrates in tears, the first line of basophil and mast cell defense against invading pathogens and allergens that frequently cause dry eye symptoms.
Lactoferrin is suggested in peer-reviewed literature to increase the level of iron binding proteins to better inhibit viral and bacterial infections and to balance other tear lipocalins (family of proteins that transport small hydrophobic molecules), which modulate the surface tension of the tear film and affect the comfort of the contact lens wearer. Lactoferrin taken orally appears to survive passage through the stomach by converting to lactoferricin (a far smaller molecule) which can easily find its way into secretory tissue including the eyes.
Background: Lactoferrin is produced in the tear film by neutrophils that constitute the “first line of defense” against infection. Neutrophil apoptosis (programmed cell death) signals the macrophage to clean up debris from wound sites, including surgically induced wounds, including LASIK.
BioTears Oral GelCaps are designed to help inhibit the LASIK induced dry eye by supporting post-surgical wound healing response, enhancing lacrimal and meibomian gland output, as well as enhance the post-op acetylcholine neurotransmitter blink response.
Ellen Troyer, MT MA Biosyntrx CEO / Chief Research Officer
PEARL: Environment really matters, including arid conditions and altitude where ocular surface health is concerned.
It’s important to note that millions of doses of BioTears Oral GelCaps formulas have been safely used by satisfied repeat dry eye customers for over ten years, including to those with LASIK induced dry eyes.
BioTears is always sold with a 60-day full-money-back guarantee so eye doctors and their patients have nothing to lose but their dry painful eye problems.
References supporting today’s Pearl and a surgical instrument announcement from our friends at Crestpoint Management can be found at this link.