A team of researchers at the University of Cincinnati have successfully treated laboratory mice with unusually thin, cloudy corneas giving hope that the impact could be replicated in humans as well.
No rejection for UMSCs
For the purpose of the study, researchers fed the mice with a diet that lacked a specific protein that is vital for the creation and preservation of a transparent cornea.
Once the vision was impaired, the human umbilical cord mesenchymal stem cells (UMSCs) that have the characteristic to mutate in a wide range of adult cell types, were introduced in the mouse cornea.
The study established that the UMSCs lived on in the cornea for three months with negligible signs of elimination or rejection. In fact, these cells took on the properties of keratocytes, the standard corneal cells.
The results of the study revealed that after the transplant of the UMSCs in the cornea of the mice, the thickness and lucidity of the animals’ corneas improved appreciably.
The cornea is the front portion of the eye and is transparent. It essentially protects the fragile structure of the eye beneath it and helps focus light.
Cloudy cornea is the loss of transparency in cornea, a condition caused by injury or certain diseases. Cloudy cornea impairs vision. Read the full story at themedguru.com