Nutrition science has advanced considerably since the Age Related Eye Disease (ARED) study formulation was designed in the late 1980s. The formulation included 28,000 IU beta carotene, 500 mg vitamin C, 400 IU vitamin E, 80 mg zinc oxide, and 2 mg copper oxide.
- When the ARED study formulation was designed over 20 years ago, science had not yet identified that excessive amounts of beta carotene interferes with xanthophyll carotenoid uptake (lutein and zeaxanthin) necessary for macula pigment optical density (MPOD).
- The connection between excessive beta carotene supplementation and increased risk of lung cancer had not been identified. The Center for Science in the Public Interest had not yet requested that the FDA require dietary supplements containing more than 5,000 IU of synthetic beta carotene include a blackbox statement warning consumers that beta carotene may cause lung cancer in smokers.
- Lutein and zeaxanthin supplementation was not available when the ARED study formulation was designed, nor had science identified zeaxanthin to clearly be the central macula preference.
- Vitamin D deficiency had not been linked to age-related macular degeneration 20 years ago.
Read the full Story at Biosyntrx Friday Pearl