Sjogren’s syndrome is a form of autoimmune disease where your body defense mechanism (immune system) attacks the organs that produce moisture. The most common symptoms are dry eye and dry mouth.
Sjogren’s syndrome related dry eyes are often severe, results in eye ulcers, corneal abrasion, Some people with Sjögren’s syndrome also have other autoimmune disorders, such as rheumatoid arthritis, systemic lupus erythematosus ( SLE), sclerosis, vasculitis, mixed connective tissue disease, Hashimoto’s thyroiditis, primary biliary cirrhosis, and chronic autoimmune hepatitis. Most Sjorgren’s patients are women.
Conventional therapy for Sjorgren’s chronic dry eye often includes eye drops – which make dry eye drier. Prescription drugs include steroids which can have side effects. Another alternative is nutraceuticals which help by restoring tear secretions.
In a research study, autologous serum drops have shown to be effective in the management of Sjogren’s dry eyes because it contain vitamins, growth factors and other components similar to natural tears. The purpose of this research study was to evaluate the efficacy and safety of AS eye drops combined with punctal plugs in patients with Sjogren’s related dry eye.
This was a retrospective study of a total of 56 eyes of 28 patients diagnosed with primary or secondary Sjogren’s Syndrome with symptoms of dry eye and a history of treatment with Autologous Serum eye drops. Schirmer test value ( measure tear volume), tear breakup time (TBUT)- measure tear viscosity- thickness, and fluorescein and Rose Bengal staining scores at baseline, 3 months, 6 months, 1 year, and >1 year after treatment were evaluated.
Conclusion – long-term application of AS eye drops was found to be an effective and safe treatment for SS dry eye.
The addition of punctal plugs in combination with Autologous eye drops was found to have an additive effect on SJogren’s dry eye. Sjogren’s require aggressive therapy in order to prevent ocular surgace damage.
This blog is a brief extract from Br J Ophthalmol 1999
Via Theralife Blog